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pentobarbital will lower the extent or impact of pioglitazone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unfamiliar.Monitor Closely (1)pentobarbital will reduce the level or outcome of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Loss of, or lessened response to t